PEPSKN The Most Advanced Copper Peptide Skin Regeneration System

A 2022 review by Spataro et al. reported that microneedling triggers the skin’s natural wound-healing cascade, stimulating fibroblast activity and new collagen formation while also enhancing the absorption and delivery of topical active ingredients.

A 2025 systematic review (Foppiani et al.) analyzed 21 studies involving 723 patients undergoing microneedling for facial rejuvenation. The most commonly evaluated improvements included wrinkles, skin texture, photoaging, and skin laxity, with 83% pooled patient satisfaction.

Microneedling works by triggering controlled skin renewal while creating temporary micro-channels that improve access of topical actives to the skin.

Clinical studies summarized in a 2018 review by Pickart et al. found that topical GHK-Cu used for 12 weeks in 71 women with photoaged skin increased skin density and thickness while reducing skin laxity, fine lines, and wrinkle depth.

Another clinical study involving 41 women found that a GHK-Cu eye cream used for 12 weeks improved the appearance of lines and wrinkles while increasing skin density and thickness compared with placebo and vitamin K cream.

Research reviewed by Pickart et al. (2015) also reported that GHK-Cu increased collagen production in 70% of treated participants, compared with 50% using vitamin C and 40% using retinoic acid.

Copper Peptides support collagen remodeling, improve skin density and firmness, and help reduce visible signs of skin aging.

A 2013 review by Du et al. in Phytotherapy Research reported that Beta-Glucan demonstrates several skin-supporting properties, including antioxidant activity, moisturization, anti-wrinkle effects, UV protection, skin penetration, and wound-healing support.

A more recent 2025 scientific review reported that Beta-Glucan possesses antioxidant, anti-inflammatory, moisturizing, and skin-barrier-repair properties, supporting its use in skin-care formulations designed for recovery and protection.

Beta-Glucan helps calm stressed skin, reinforce the skin barrier, support hydration, and defend against oxidative damage.

A 2021 clinical study by Draelos et al. in Dermatology and Therapy evaluated a topical Hyaluronic Acid serum in 40 women with facial photoaging. Skin hydration increased by 134% immediately after application and remained 55% above baseline after 6 weeks, alongside improvements in smoothness, plumping, fine lines, and overall appearance.

A 2000 randomized, double-blind, placebo-controlled study by Gehring & Gloor found that topical Panthenol significantly increased stratum-corneum hydration and reduced transepidermal water loss, supporting improved skin-barrier function.

Hyaluronic Acid attracts and retains moisture while Panthenol helps strengthen the skin barrier and reduce moisture loss for longer-lasting hydration.